Arthrosi Therapeutics, Inc., a clinical-stage biopharmaceutical company pioneering innovative small-molecule therapies for gout and other inflammatory diseases, has successfully raised $153 million in Series E funding. The round was led by Prime Eight Capital Limited, alongside CR Biotech, HighLight Capital, HM Venture Partners, ReliantTech Limited, and other existing shareholders  -  marking a major milestone in Arthrosi’s journey to redefine chronic disease management.

Under the leadership of Litain Yeh, Founder and CEO, Arthrosi Therapeutics continues to make significant strides in developing next-generation urate-lowering and anti-inflammatory treatments, with the goal of improving the quality of life for millions of patients worldwide.

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A Major Step Forward in Gout and Inflammation Therapy

The global prevalence of gout, a painful inflammatory arthritis caused by excess uric acid, has been steadily increasing. According to the Global Burden of Disease Study, over 41 million people globally are affected by gout, a number projected to grow as lifestyles and diets continue to evolve. Despite its prevalence, current therapies often come with safety concerns, limited efficacy, or poor patient adherence.

Arthrosi Therapeutics aims to change that narrative.

Its leading candidate, AR882, represents a new generation of selective uric acid reabsorption inhibitors, targeting the underlying cause of gout rather than just managing its symptoms. By blocking the URAT1 transporter in the kidneys, AR882 helps the body efficiently eliminate uric acid  -  a more targeted and sustained approach to treatment.

The newly secured funding will accelerate late-stage clinical trials of AR882 and expand research into other inflammatory pathways relevant to chronic conditions.

“This new funding allows us to move one step closer to providing patients with safer, more effective long-term treatment options,” said Litain Yeh, CEO of Arthrosi Therapeutics. “Our vision has always been to address the root cause of inflammation, not just the pain.”

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The Science Behind Arthrosi’s Innovation

Arthrosi’s research sits at the intersection of precision medicine and molecular innovation. Its small-molecule therapies are designed to selectively target disease mechanisms while minimizing off-target effects  -  a balance that has long eluded existing treatments.

While AR882 leads the pipeline, Arthrosi is also advancing next-generation compounds focused on inflammation-related metabolic disorders. The company’s approach emphasizes mechanism-driven design, ensuring that each molecule addresses a specific biological trigger rather than broadly suppressing immune responses.

This model enables more predictable outcomes and significantly lower side-effect profiles, aligning with a growing industry trend toward patient-centric pharmacology.

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The Power of Deep Focus in Biotech

Many biotech founders chase multiple indications to attract investor attention  -  but Arthrosi’s story demonstrates the power of focus. By concentrating relentlessly on one specific mechanism (urate reabsorption inhibition) and building world-class expertise around it, the company has managed to stay ahead in both speed and accuracy of clinical development.

Founders across all sectors can learn from this: scaling impact often means narrowing scope, not expanding it.
The deepest value lies in building mastery over a problem space until innovation becomes second nature.

This kind of strategic precision  -  deeply understanding one biological system or customer pain point  -  not only drives product excellence but builds credibility that compounds over time. In biotech, where trust is currency, Arthrosi’s disciplined focus is its biggest competitive advantage.

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Why Investors Are Betting Big on Arthrosi

The Series E round is more than just a financial milestone  -  it’s a strong vote of confidence from investors who see Arthrosi’s technology as a key enabler of next-gen inflammation management.

• Prime Eight Capital Limited and HighLight Capital, both known for investing in breakthrough life sciences companies, recognize the company’s potential to disrupt a market where innovation has been stagnant.
  
• HM Venture Partners and CR Biotech add strategic depth, bringing experience in drug development, regulatory pathways, and commercialization within both U.S. and Asian markets.
  
• Existing shareholders’ participation underscores long-term confidence in Arthrosi’s clinical pipeline and leadership.
  

This cross-border investment strategy also signals a broader global shift toward chronic disease innovation, with Asia-based investors increasingly backing Western biotech startups focused on scalable, science-backed therapeutics.

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Gout Treatment: A Market Ready for Disruption

According to Fortune Business Insights, the global gout therapeutics market was valued at $2.4 billion in 2023 and is expected to surpass $3.8 billion by 2030, driven by aging populations, dietary changes, and rising metabolic disorders.

However, despite the size of this market, innovation has been slow. Existing drugs like allopurinol and febuxostat, while effective for some, often fall short for patients with comorbidities or drug sensitivities. In contrast, AR882’s mechanism of action is designed for higher efficacy, fewer adverse events, and better patient compliance  -  all of which could position Arthrosi as a category leader in modern gout therapy.

Moreover, Arthrosi’s research extends beyond gout, tapping into broader inflammation biology  -  potentially opening doors to adjacent markets such as chronic kidney disease (CKD), cardiovascular inflammation, and metabolic syndrome.

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The Biotech Industry Outlook: Precision Medicine Meets Scalable Innovation

The global biotech industry continues to thrive despite macroeconomic headwinds. According to McKinsey, biotech innovation now accounts for over 20% of global R&D pipelines, with venture investment rebounding to over $50 billion in 2025, largely driven by breakthroughs in gene editing, AI-assisted drug discovery, and precision therapeutics.

Small-molecule innovation  -  Arthrosi’s specialty  -  is experiencing a renaissance. These therapies, which once defined early drug discovery, are now being reimagined with computational modeling and structure-based design, allowing for better selectivity and faster preclinical turnaround times.

As regulatory frameworks evolve to accelerate approval for targeted therapies, companies like Arthrosi are perfectly positioned to lead a new wave of efficiency-driven biotech growth.

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What’s Next for Arthrosi Therapeutics

With its Series E funding, Arthrosi plans to:

• Advance AR882 into pivotal Phase III trials.
  
• Expand its R&D capabilities for next-gen anti-inflammatory molecules.
  
• Strengthen global partnerships to support commercialization and regulatory engagement.
  
• Continue building a world-class leadership team focused on translational medicine.
  

“Our mission is to redefine the future of inflammation treatment  -  one molecule, one patient, one success at a time,” Yeh added. “With this new funding, we’re moving closer to making that vision a global reality.”

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Final Thoughts: Building the Future of Inflammation Science

Arthrosi’s Series E funding marks not just a financial win but a scientific validation of its strategy  -  marrying deep molecular insight with a patient-first mindset.

In an era where chronic conditions are on the rise and healthcare systems are stretched thin, innovations like AR882 represent more than new drugs  -  they’re symbols of hope, precision, and smarter medicine.

Arthrosi Therapeutics is proving that true innovation doesn’t just treat diseases  -  it reshapes how we understand and conquer them.